降圧劑投與による腦波變化にかんする實驗的ならびに臨床的研究

第2編 降圧劑を注射したさいの高血圧症患者腦波の變化について

抄録

The electroencephalographic responses in 52 hypertensive subjects induced by injection of clinical dosis of antihypertensive drugs were observed and factors producing the electroencephalographic responses were studied.
In 37 cases among 52 hypertensive subjects electroencephalographic responses were recognized after injection of the drugs and in 12 cases of them prominent responses were observed.
The author investigated correlations between the electroencephalographic responses and various clinical findings.
As a result, it was found that the electroencephalographic responses might be influe-enced by following factors:
1) initial systolic blood pressure,
2) initial diastolic blood pressure,
3) rate of decrease in the systolic blood pressure,
4) rate of decrease in the diastolic blood pressure, and
5) arteriosclerotic degree in retinal back ground.
In the cases showing prominent electroencephalographic responses, marked disrhyth-mias and disorders in, the electroencephalogram like as the epileptic seizure patterns were observed in 4 cases, the paroxysmal slow wave bursts with or without spikes, in 7 cases, and the disappearance of slow wave bursts which were seen before the injection, in one case.
Focal electroencephalographic responses in a wide sense were found in 4 cases.
From these results, the administration of the antihypertensive drug, even though within its clinical dosis, may produce frequently the electroencephalographic responses suggesting cerebral vascular insufficiency in hypertensive subjects with high initial blood pressure and cerebral arteriosclerosis of high degree. Therefore, when antihypertensive drug is injected in hypertensive subject, special attention must be paid.
The injection caused sometimes the symptoms alarming the dosage of antihypertensive drug, but if it is used carefully, it is harmless and may be useful for the determination of the focus in the brain and for the activation of electroencephalogram in epileptics.