1958 Volume 46 Issue 12 Pages 1527-1535
A given quantity of cysteine injected intravenously in the normal rabbits produced two peaks in leucocyte count, but the second peak disappeared when the cervical cord was severed. In the rabbits with the liver injured by CCl4, cysteine showed same tendency as in the normal rabbits. There appeared, however, a marked first peak and a diminished low second peak. These facts show that the leucocyte increase occurs in two ways such as the peripheral first and the central second peak.
Now with the purpose of clarifying these relations, investigations have been made as to which leucocyte-increasing peak Neutrophilin (Neutropoetin-Komiya) is proved in the serum-Neutrophilin which is inevitably produced in the serum at the time of the central leucocyte increase. The results are as follows:
1. The serum three hours after the administration of cysteine did not contain Neutrophilin. The first increasing peak (appeared three to four hours later), therefore, was caused peripheral-produced by the direct stimulation of the hematopoietic organs and it was not the “central” leucocyte increase.
2. The existence of Neutrophilin was proved in the serum 7 hours after the administration of cysteine. The second peak (occured 8 hours later), therefore, was the central leucocyte increase.