CLINICAL STUDIES ON THE CIRCULATION OF ASCITIC FLUID

Abstract

On the various diseases with ascites, the transfer rate of albumin was investigated by using radio iodinated human serum albumin (IHSA), following the intravenous and intraperitoneal injection. The results obtained were as follows:
(1) The turnover rate of albumin following intravenously injected IHSA was decreased in patients with ascites. It's rate and albumin pool in tuberculous peritonitis and carcinomatous peritonitis were greater than those in cirrhosis of the liver and Banti's syndrome.
(2) The disappearance rate from the plasma following intravenously injected IHSA was increased in patients with ascites.
(3) The transfer rate of albumin in patients with ascites showed the value of 0.591g per hour in cirrhosis of the liver and Banti's syndrome, and 1.7g per hour in tuberculous peritonitis and carcinomatous peritonitis with intravenously injected IHSA. It's rate of intraperitoneally injected IHSA was 0.341g per hour in cirrhosis of the liver and 0.816g per hour in carcinomatous peritonitis.
(4) The transfer rate of albumin into the ascites was parallel to the clinical course of cirrhosis of the liver and it's rate was decreased and the turnover rate of albumin increased according to the clinical remission following intravenously injected IHSA.
(5) The disappearance rate from the plasma of intravenously injected IHSA was decreased and the excretion of I¹³¹ increased in the cases which had showed the significant effect with mercurial diuretic.
(6) The transfer rate of albumin was decreased after abdominocentesis following intravenously and intraperitoneally injected IHSA.