病巣感染の成因にかんする研究

とくにそのアレルギー機序について

抄録

In an attempt to clarify the allergic mechanism for the pathogenesis of focal infection, immunological tests were performed on rabbits with extracts obtained from their foci used as antigen, following the animals were injected with streptococcus into the abscess which had been produced by Alloilonat administered.
From the results of Schultz-Dale's test, skin test, precipitation test and Prausnitz-Küstner's tests, it was found that an antibody against products of inflammatory focus was present in sera and tissues of rabbits with focal infection. This antibody was different from any antibody against culture filtrates of streptococcus. The development of this focal antibody was the highest 4 or 5 weeks after the beginning of experimentation. It was revealed that an antigenic factor in extracts of foci consisted in their protein fractions especially in euglobulin fraction.
Clinically it was also demonstrated that the focal antibody was present in sera of patients with chronic tonsillitis, acute rheumatic fever and erythematodes.
Furthermore, a new antigenic factor different from a focal or bacterial antigen, was found in sera of patients with acute rheumatic fever. This factor disappeared after the treatment with prednisolone. It was not present in sera of patients with tonsillitis. A similar antigenic factor was also demonstrated in sera of rabbits with focal infection 4 or 5 weeks after the beginning of experimentation.
It is concluded that the allergic mechanism related with focal antigen should be taken into consideration when the pathogenesis of focal infection is discussed.