ECOLOGICAL STUDIES ON THE BACTERIAL FLORA IN THE UPPER RESPIRATORY TRACTS
(2) INOCULATION TEST TO THE NASAL MUCOUS MEMBRANES BY MICROCOCCUS PYOGENES VAR. AUREUS
1958 Volume 47 Issue 2 Pages 88-93
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1958 Volume 47 Issue 2 Pages 88-93
We reported that we had recognised the increase of Penicillin resistant micrococci pyogenes by the studies on the bacterial flora in the upper respiratory tracts for ten years from 1948 to 1957, but this increase generally has been considered as a results of the cross-infection of Penicillin resistant strains.
However we have suspected whether it was truely the result of the cross-infection, or by mutation of Penicillin-sensitive strains and other mechanism, therefore we performed inoculation test to the nasal mucous membranes of volunteers by micrococci pyogenes.
The next method was taken for inoculation test; namely (I) inoculation of the strains cultured in liquid media to the noses of volunteers only one time, (II) inoculation of physiolgical saline suspension of the strains to the noses of volunteers daily for one week, (III) direct inoculation from the noses of the carriers of micrococci pyogenes to the noses of volunteers, etc.
The results of the test did not come out as we expected.
These results, we consider, show the cross-infection of Penicillin-resistant micrococci pyogenes do not happen so easily.
