1958 年 47 巻 8 号 p. 945-954
Hepatotonics including sodium hippurate and sodium dehydrocholate were injected to mice to stimulate their hepatic function. Nephrectomy was also performed on rabbits for the same purpose. Their livers were excised and subjected to electron microscopy after the conventional fixation and section. The results obtained in this study are summarized as follows.
1) There was no appreciable change in the morphology of mitochondrias in the polygonal cells of the liver.
2) There was an increase in the number of endoplasmic reticulum and its associated Palade's particles, in the polygonal cells which was thought to be related to the accelerated functional state of the liver. Increased number of endoplasmic reticulum and Palade's paticles may be a prominent morphological indicator of accelerated hepatic function.
3) Injection of sodium dehydrocholate which is a cholagogue resulted in the enlargement of the endoplasmic reticulum and the appearance of small vesicular components in the polygonal cells. These changes were understood as the morphological picture of accelerated secretion of bile.