動脈硬化の定量的臨床測定を求めて

抄録

I have developed three methods to measure the degree of arteriosclerosis non-invasively and quantitatively.
(1) Pulse wave velocity (PWV) : PWV has become very useful in solving the following PWV problems: To neglect the effect of vasomoter activity, PWV was measured at aorta; also as PWV depended on blood pressure, a corrected blood pressure nomogram was made; and PWV was estimated from good correlation with the grade of pathological changes (γ=0.86) .
(2) Ultrasonic quantitative flow measurement system (QFM) : QFM which can measure absolute carotid flow volume was developed to diagnose carotid and cerebral arteriosclerosis. It was found that flow volume decreased with aging and on the involved side in ischemic cerebrovascular disease.
(3) Simulation method: To measure cerebral arteriosclerosis, a simulation method was developed. Parameters Rp, Cp indicating the degree of cerebral arteriosclerosis were calculated by feeding (a) carotid phasic flow volume measured using QFM, and (b) the carotid pressure wave into the simulation model of the carotid and cerebral vascular system. By pathological study, Rp was clarified as correlating well with lumen narrowing (γ=0.78), and Cp with the wall thickness ratio (γ=-0.61) .
QFM and simulation method was of great use in estimating cerebral arteriosclerosis quantitatively.