Neurosonology:神経超音波医学
Print ISSN : 0917-074X
ISSN-L : 0917-074X
慢性期脳血管障害の薬物療法―総頸動脈血流動態に対するSK-827の効果―
山野 繁澤井 冬樹小松 正佳森岡 泰子嶋 宏子森本 真弓濱口 尚重土肥 和紘籠島 忠石川 兵衛
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1992 年 5 巻 3 号 p. 56-63

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This study was performed to clarify the effects of kallidinogenase (human urine) (SK-827) on the common carotid hemodynamics in patients with old cerebral thrombosis.
A total of 11 patients including 6 males and 5 females were examined in this study, with ages ranging from 65 to 78 years (mean: 72 years) . Six patients were intravenously administered 0.15 PNA (p-nitro-aniline) units for 30 minutes and the other 5 were administered 0.30 PNA units in the same way. The common carotid hemodynamics was evaluated by ultrasonic quantitative flow measurement system (QFM-1000) before administration and 15, 30, 60 and 120 minutes after administration. Mean blood flow and mean blood velocity of the common carotid artery showed a significant increase, while cerebral circulatory resistance showed a significant decrease at 15 and 30 minutes after SK-827 administration. There were no differences between administration of 0.15 PNA units and 0.30 PNA units in the effects of SK-827 on the common carotid hemodynamics.
These results indicate that intravenous SK-827 administration may have beneficial effects on the common carotid hemodynamics in patients with old cerebral thrombosis.

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