中枢神経損傷後の海馬内neurogenesis活性化機構の解析

抄録

Although neurogenesis is observed in human adult brain, its regulation mechanism and role are unknown. Among lots of factors promoting neurogenesis, we focused on fibroblast growth factor-2 (FGF-2), one of the most important factors for neural stem cell culture. In our study, neurogenesis was upregulated in dentate gyrus (DG) following traumatic brain injury as well as cerebral ischemia and kainic acid-induced seizure in wild type mice, but the upregulation was reduced in FGF-2 knockout mice. When FGF-2 was overexpressed using gene transfer technique with herpes amplicon vector, neurogenesis was upregulated, and, furthermore, degenerative changes of hippocampus after traumatic brain injury were also reduced. These results suggested that FGF-2 is a critical factor to regulate neurogenesis in DG after brain injury. Administration of growth factors after brain injury may provide a strategy for repair of the brain following neuronal injury and other CNS disorders.