Effect of the rare sugar D–allose on trauma at the neuronal level caused by intracerebral hematoma

抄録

Traumatic or non–traumatic intracerebral hemorrhage (ICH) increases the intracranial pressure, leading to disabling hematomas. Iron in the hematoma causes secondary disorders such as inflammation and edema. D–allose, a rare sugar, exerts antioxidant and anti–inflammatory effects. We investigated the effects of D–allose on secondary disorders after ICH. ICH model rats were created by injecting autologous whole blood (100 μL) into the right basal ganglia of adult Sprague–Dawley rats. D–allose (200–400 mg/kg) was admin­istered intraperitoneally immediately after establishing the model. A battery of motor deficit tests was ex­amined 1 day after administration, and brain edema, doses of an oxidative stress marker (8–OHdG, apurinic ⁄ apyrimidinic (AP) site) and inflammatory cytokines (IL–1β, IL–6, TNF–α) in the brain were examined 3 days after administration. All the examined items showed that D–allose significantly suppressed the damage. These results suggested that D–allose suppresses secondary damage following ICH. D–allose is expected to have potential as a therapeutic agent for secondary disorders after ICH.