Japanese Journal of Cognitive Neuroscience
Online ISSN : 1884-510X
Print ISSN : 1344-4298
ISSN-L : 1344-4298
Correlation between levels of medial temporal atrophy and scores of Rivermead Behavioural Memory Test in patients with early Alzheimer disease
Tomiko NagayamaTakuya NakayamaKenshiro SatoSunghoon YangShuhei YamaguchiMasao Nagayama
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2021 Volume 22 Issue 2 Pages 98-104

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Abstract

Voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD) is a new software program using magnetic resonance imaging (MRI) for the detection of early specific atrophy in Alzheimer’s disease (AD). The target volume of interest (VOI) is the medial temporal region involving hippocampus, amygdala, and the entorhinal cortex. These regions, especially the hippocampus are concerned with memory function.

The purpose of this study was to assess whether there was a significant correlation between the severity score of atrophy in the target VOI and the Rivermead Behavioural Memory Test (RBMT) score that is a memory function test in everyday life scenes in the patients with early AD.

This study included 59 patients, and they were classified as FAST3 (borderline between normal and mild AD) or FAST4 (mild AD). The Mini-Mental State Examination (MMSE) that is the most widely used screening tool for detecting dementia and a general cognitive function test, and the RBMT were administered to all patients. Out of the total patient pool, 32 patients were scanned with a 1.5Tesla MRI scanner and 27 patients were scanned with a 3Tesla MRI scanner. Their levels of medial temporal atrophy were then analyzed by VSRAD using the brain MRI data.

We found that there were more significant correlations between the severity score of atrophy in the target VOI and the RBMT score than the MMSE score.

These findings suggest that the RBMT is useful in detecting the early AD.

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© 2021 Japanese Society of Cognitive Neuroscience
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