熱傷瘢痕癌の電子顕微鏡的研究

第2編: 癌巣の有棘層相当部

抄録

Electron microscopic study on squamous cell carcinoma in burn scar revealed the followings, concerning the prickle-cell layer of cancer nests. Nuclei of the cells which arranged lamellarly exhibiting little tendency of keratinization and so seemed to be in the biginning stage of cancer pearl formation (hereafter refered to as B. P. F.) mostly flattened, being dislocated in one side of the cytoplasm, and often showing saw-toothed border. Most of their nucleolei were not so large in size but commonly displayed distinct nucleolonemata. The cancer cells located in the center of B. P. F. were filled with many tonofibrils distributed in their cytoplasm showing meshy arrangement, while peripheral cells contained fine or thick bundles of tonofibrils arranged in concentric whorls surrounding the center B. P. F. Intercellular spaces between cancer cells were mostly narrow or indistinct, but occasionally vacuolarly dilated. In such portions desmosomes were often lengthened. Round-shaped or horseshoe-shaped structures, a portion of which contained desmosomes or desmosome-like structures were recognized in the cytoplasm of cancer cells located in the center of B. P. F. The cytoplasm of cells showing individual cell keratinization was packed with inocmpletely keratinized tonofibrils of various sizes and random orientations with the disappearance of cytoplasmic organelles. It occasionally contained desmosomes or round shaped structures presumed to be derived from the tight junction.