油症の脂質代謝

第1報: 薄層クロマト法,およびガスクロマト法による血清脂質分析

抄録

In 1968, the patients complaining of acneform eruption have been mainly discovered in Nagasaki and Fukuoka prefectures. It has been proved that this disease is caused by the rice oil contaminated with chlorobiphenyl during the purification process and designated so “Yusho (chlorobiphenyl toxication)” at the basis of the clinical findings and pathogenesis. This report describes analyses of serum lipids of Yusho patients and control by thin layer chromatography and gas chromatography.
1) In serum, comparing with controls, levels of free fatty acid and triglyceride were elevated, but that of cholesterol ester was low among these patients. Thre fore, it was assumed that high levels of these two fractions in serum were maintained by the increase of synthesis of triglyceride in liver as the result of an increase of the release of free fatty acid from adipose tissue. It was also assumed that high triglyceride level in serum was caused by the shift of equilibrium between free fatty acid and triglyceride in liver as the result of an increase of release of free fatty acid from adipose tissue.
2) On fatty acid composition analyses of free fatty acid, triglyceride and cholesterol ester fractions by gas chromatography, significances between Yusho and controls were observed.
3) The significant correlation between liver function and lipid and its fatty acid composition in serum were not observed, suggesting the disturbance of lipid metabolism in adipose tissue of Yusho patients.
4) It is observed that the serum triglyceride level of the patients treated for one year decreased to normal range.
5) From the serum lipid analysis it is apparent that Yusho and acne vulgaris showed difference in composition of serum lipid.