熱傷瘢痕の癌化に伴う細胞微細構造上の変化

抄録

Clinical and histopathological observations revealed that burn scars seemed to develop into squamous cell carcinoma via following intermediate stages; (1) atrophic changes, (2) acanthotic changes and (3) acanthotic changes with atypical cells (referred to hereafter precancerous condition). Based upon the avove results, ultrastractural comparisons of the keratinocytes in each of these intermediate stages as well as in squamous cell carcinomas developed on burn scars were performed and obtained following results: 1) keratinocytes in the above precancerous condition displayed nuclei which contained large nucleoli with distinct nucleolonemata, numerous perichromatin granules, and nuclear bodies; The cytoplasm contained well-developed rough endoplasmic reticulum with tubular cisternae and free ribosom es forming polysome; Tonofibrils decreased in number and were irregularly distributed; Desmosomes were scanty and intercellular spaces were mostly widened; Basal laminae often showed irregularity in width and electron density, and/or partial discontinuity; 2) The above changes were observed more conspicuouly in keratinocytes in cancer nests (cancer cells), and increased in grade with the advancement of Broders’ grade of malignancy.