エリテマトーデスとリンパ球

抄録

Three studies were carried out on the lymphocytes of the patients with Lupus Erythematosus in order to: (1) look for chromosomal aberrations in peripheral lymphocytes; (2) examine the function of immunologically competent lymphoid cells (cellular antibody); (3) determine the presence or absence of immunoglobulin production by cultured peripheral lymphocytes. Various chromosomal aberrations were frequently observed in cultured lymphocytes from patients with SLE, but few in DLE. Significantly increased frequency of chromosomal aberrations in SLE, especially G group chromosomal abnormalities including G trisomy, suggests that there is an association between chromosomal abnormalities and autoimmune disease. The examination of delayed hypersensitivity indicated that there was a functional failure of immunologically competent lymphoid cells in SLE. The direct immunofluorescent staining showed that PHA stimulated lymphocytes from patients with SLE contain γ-globulin, IgG and IgM. It seems likely that these cells produce each immunoglobulin.