Abstract
Ten patients with melanosis faciei feminus were treated by oral administration of 600 mg per day of vitamin E (α-tocopherol nicotinate), 600 mg per day of vitamin C, application of cream containing 2% vitamin E (α-tocopherol), and the following results were obtained. Both the serum level of lipoperoxide and the proportion of lipoperoxide to total lipids decreased significantly in the treated patients. The sebum level of li pperoxide decreased in the group of patients given cream containing 2% Vitamin E, while no similar effect was noted in the group given a placebo (i.e. base only), the measurements of the skin color taken by a color difference meter were in agreement with the results of gross inspection. The difference in color value between the pigmented area and the non-pigmented areas was significantly decreased in the treated group, whereas no significantly effect was noted in the control group. There was a close correlation between variations in sebum level of lipoperoxide and measurements of color value taken by a color difference meter.
