治療
コンビペニックスの皮膚科領域における臨床的実験的研究
1978 年 40 巻 3 号 p. 489-495
詳細
1978 年 40 巻 3 号 p. 489-495
A combined antibiotic drug, Combipenix, (ampicillin and dicloxacillin) was evaluated clinically and experimentally.
1) Combipenix was administered to 30 patients with infectious skin diseases and found to be very effective in 3 cases, effective in 25 cases and ineffective in 2 cases. As a side effect, the gastric irritation was observed in 2 patients of them.
2) Organisms isolated from clinical specimens were mainly Staphylococcus aureus and S. epidermidis.
3) MIC of 21 organisms was measured and this combined antibiotic drug was confirmed to have potentiation actions on the experimental studies. Especially MDI-PC was very effective for Staphylococcus, while some strains of Staphylococcus were resistant to AB-PC.
4) On the experimental studies in rabbits, both AB-PC and MDI-PC concentrated more in the blood than in the skin. MDI-PC levels in the skin was lower than that of AB-PC.
5) Combipenix is considered to be a safe and effective drug for infectious skin diseases.
