整形外科と災害外科
Online ISSN : 1349-4333
Print ISSN : 0037-1033
ISSN-L : 0037-1033
c-Cb1 の過剰発現による骨肉腫細胞抑制についての検討
上野 宜功横内 雅博大西 敏之安田 いづみ二之宮 さやか小宮 節郎井尻 幸成
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2002 年 51 巻 4 号 p. 779-781

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The protein product of the c-Cb1 proto-oncogene is involved in several signaling pathways and exerts a negative regulatory function on receptor and non-receptor tyrosine kinase. We used the overexpression experiment, and demonstrated that the c-Cb1 inhibits phosphorylation of intracellular protein in osteosarcoma cell line, SaOS2. Luciferase reporter assays revealed overexpression of c-Cb1 suppressed PDGF-induced c-Fos promoter activity as well as v-Src-induced STAT3 promoter activity. Thus, our results demonstrate that c-Cb1 negatively regulates several signaling pathways in the osteosarcoma cell line, suggesting that c-Cb1 is a good candidate for gene therapy against osteosarcoma.

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© 2002 西日本整形・災害外科学会
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