Myxoid liposarcoma is thought to be insensitive to chemotherapy. This time, we applied a new chemotherapy to some cases of myxoid liposarcoma, and found that the treatment is very effective. The results were as follows: Case 1 was a 41-year-old female treated with three courses of systemic chemotherapy with IFM, ADM, CDDP (IAP therapy). (IFM 2g/m 2, ADR 20mg/m 2, CDDP 20mg/m 2 was administered for three days in succession, and stopped for the next two weeks. This series consists of one course of full dose of IAP therapy.) Case 2 was a 51-year-old female treated with three courses of IAP therapy with 2/3 dose, and with five courses with 1/3 dose. Case 3 was a 28-year-old male treated with two courses of IAP therapy with a full dose, combined with 45Gy radiotherapy. One case showed CR, and two showed PR. These results indicate that IAP therapy is effective for myxoid liposarcoma.