2004 年 53 巻 1 号 p. 155-162
A two-year-old girl visited the orthopedic clinic of Fukuoka University Hospital in July 1974, complaining of leg- and wrist deformities. She was diagnosed as rickets and prescribed vitamin D alone. 1αOH D3 was prescribed from 1963. It was used at the maximum dose of 30 μg/day at the end of 1979. The dosage of 1α (OH) D3 was reduced from 1980. Since 1993 she had been treated with phosphate and 1α (OH) D3. Leg deformities were corrected with the administration of 1αOHD3 alone. After correction of the leg deformities, she suffered malunion of her left tibia. This caused valgus deformity of the tibia and was followed by secondary femur deformity. Correction oseotomy of the tibia alone was performed because she refused femur osteotomy. This procedure failed to improve leg deformity and the deformity of the tibia recurred. From 1984 October to 2002 February, the therapy was interrupted numerous times, because. she skipped her visits. This time she visited us twice, complaining of leg pain due to Looser's transformation zone in both the femur and tibia after long-term interruption of the therapy. The Looser's zones healed by medication and use of a cane. Since 2002 February, she has been continuing her therapy with her daughter who has also been diagnosed as hypophosphatemic vitamin D resistant rickets.