Giant cell tumors (GCT) of hand bones are uncommon and reported more biologically aggressive than those elsewhere. A 17-year-old man with GCT in the right second metacarpal is presented. Physical examination of the dorsal hand showed a mild tenderness with moderate swelling but no erythema. Results from laboratory tests were within normal limits. Radiographs showed an osteolytic lesion in the bone of the metacarpal. CT revealed a mass lesion in the second metacarpal, and evidence of destruction of the volar cortex was present. MR imaging demonstrated a mass lesion in the metacarpal, which was iso intense on T1-weighted and slightly high intense on T2- weighted images. The lesion was obviously enhanced by Gd-DTPA and the cortex was thinned but there was no definite evidence of extraskeletal extension. A complete curettage of the lesion and bone graft was performed through a dorsal approach. The pathological findings were compatible for bone GCT. There was no evidence of local recurrence or metastatic disease two years after surgery.