We evaluated the toxicity and feasibility of chemotherapy for patients with soft tissue sarcomas. A total of 13 patients were treated in our department from 1998 to 2003. The median age of the patients was 42.6 years. The patients were treated with a combination of IFO + ADM + CDDP (11 courses), IFO + EPI (10 courses), or IFO + ADM (43 courses), or IFO (6 courses). Toxicities were assessed according to the National Cancer Institute-common toxicity criteria. Hematologic toxicities were anemia (29% grade 3 and 4), leukopenia (99%), neutoropenia (100%) and thrombopenia (13%). Nonhematologic toxicities were mainly nausea or vomiting (grade 1 and 2).
All courses were completed despite the occurrence of these toxicities.
Chemotherapy using high-dose IFO and ADM proved feasible with intense supportive treatment in adult soft tissue sarcomas.
