Roentogenographic observation has been made on bony changes in twenty-seven patients with renal failure during dialysis, and histopathological examination of bone specimens was carried out in six cases.
Subperiosteal resorption of bone and radiolucent cyst-like lesion as seen in hyperparathyroidism were present in seventeen patients, focal and extensive demineralisation in seven, ricket-like lesion in five, periosteal thickening in two and ostesclerosis in one. Demineralisation of bone was predominantly found in the specimen from spine and femur in 5 cases. Bone biopsy of a rib with Villanueva tetrachrome staining (Frost) showed the evidence that the activity of bone formation and bone resorption were raised to a greater degree and osteoid seam markedly increased in as well as width.