Many inveseigators have made efforts to produce a model arthritis, which is consistently reproducible in animals, with the aim at further investigation into the pathogenesis of osteoarthritis. We have challenged to produce the ostearthritic conditions by making unstable joints in rabbit knees with surgical procedure.
Degenerative changes were studied not only histochemically but also utilizing the cryoscanning E. M. and T. E. M. and were reported for the past two times.
On this occation, we have compared the findings of the experimental osteoarthritic cartilage, five to seven weeks postoperatively, with those of human osteoarthritic cartilage.
Some similarities; i. e, the characteristic features of osteoarthritis namely fibrillation, and fissuring of articular cartilage with loss of acid mucopolysaccharide stainning were observed in both of them.
