44 rheumatoid patients treated by D-Penicillanine during the peroid of 4 to 28 months were estimated clinically and by serological examination. The changes in ESR, CRP, LFT, RAHA, Hb, A/G ratio were measured monthly as the parameters. 34 patients (77.3%) improved, within whom 25 patients (73.5%) showed the effect until 3 months. Adverse reactions appeared on 79 % of the patients with the withdraw of 7 patients (15.9%); 22 cases in dermatologic reaction such as itching and eruption, 8 patients in gastrointestinal upset, 6 patients in proteinuria and 4 patients in loss of taste.
