1980 年 29 巻 1 号 p. 164-167
To clarify the biochemical characteristics of soft part tumors, we studied acidic glycosaminoglycans in the extracts of malignant fibrous histiocytomas and liposarcomas by colorimetric analysis combined with two dimensional electrophoresis.
The results were as follows:
1. Uronic acid content was greater in amount in liposarcomas than in malignant fibrous histiocytomas.
2. Hyaluronic acid was found to be above 80% of total acidic glycosaminoglycans in liposarcomas.
3. Hyaluronic acid, dermatan sulfate, chondroitin 4, 6 sulfate and heparan sulfate were found in malignant fibrous histiocytoma.
Our preliminary data suggests that acidic glycosaminoglycans analysis makes it possible to differentiate malignant fibrous histiocytoma from liposarcoma.