Between 1964 and 1974, 105 patients with osteosarcoma were admitted to our clinic, in which 75 patients were operated radiclly and 65 of them were followed up for five to ten years. A five years survival was of all cases was 24%. Systemic adjuvant chemotherapy for patients with osteosarcoma has been given in our clinic since 1963. Comparison the rerults of the group treated before and after 1963 showed a marked difference (16% and 28%). Though the result of the group treated after 1975 cannot evaluate because of the shortage of the follow up, a better result will be expected.