Effect of Vitamin E on Platelets Changes Associated with Decompression

抄録

The influence of vitamin E on platelets changes of rats associated with decompression was studied. In the first study, rats stayed at 6 ATA for 2 hours and were decompressed in 15 minutes, and platelet count fell from 56.13±4.14×10⁴/mm³ to 39.06±12.98×10⁴/mm³ after decompression.
In the second study, rats were devided into 3 groups: group A rats were fed vitamin E-deficient diets (tocopherol 3mg/kg), group B rats were fed control diets (tocopherol 18mg/kg), and group C rats were fed vitamin E diets (tocopherol 18mg/kg). These groups were fed for 3 months. Platelet count fell from 64.84±3.70×10⁴/mm³ to 56.66±5.03×10⁴/mm³ after decompression in group A. Platelet count fell from 56.28±3.12×104/mm³ to 45.62±13.84×10⁴/mm³ in group B. But there was no significant changes of platelet in group C. In the third study, survival rate after decompression was studied. Highest survival rate was group C (50.0%) and lowest survival rate was group A (16.7%). These results suggest that platelets changes after decompression can be inhibited by vitamin E. Vitamin E seemed to inhibit platelet adhesiveness and aggregation after decompression.