1981 年 30 巻 1 号 p. 208-212
In seventy cases of senile osteoporosis, serial plasma levels of Gc as well as PTH, Ca, P, vitamin A-binding protein and prealbumin were followed by simultaneous assays to investigate changing interrelations. The patients showed lowered plasma Gc levels though the decrease was not as marked as in patients with cirrhosis of the liver. The plasma Gc changes did not parallel changes in RBP or PA. There was no plasma Gc changes that could be corrected with any of such parameters as PTH, Ca and P. The data indicate that the lowered plasma Gc concentration provides a common background to all cases of senile osteoporosis and suggests that PTH, Ca and P do not control the plasma Gc levels, which may be mediated through an independent regulatory mechanism.