1981 年 30 巻 2 号 p. 337-352
1. Our clinical study seemed to indicate that the intra-articular injection of dexamethasone phosphate is much more effective in relieving the knee symptoms of rheumatoid arthritic and osteoarthritic patients.
2. Dexamethasone phosphate was much more easily hydrolysed in the synovial fluid than in dexamethasone sulfate.
3. Intra-articular injections of glycosaminoglycanpolysulphate appeared to have some favorable effects on the degenerated articular cartilages, however, they did not limit the progression of the degenerative changes in the experimental osteoarthrosis of rabbit knee.
4. Double-blind controlled trials confirmed that the intra-articular injection of glycosaminoglycanpolysulphate was useful for osteoarthrosis of the knee. The trials also indicated that the dosage of 50mg was more useful than that of 25mg or 100mg.
5. Intra-articular injections of superoxide dismutase did not cause any marked changes of the articular and semilunar cartilages of a rabbit knee.