The effects of high doses of EHDP on the healing process of non-immobilized fractures in young female rats tibia were observed roentogenographically and histologically.
EHDP (60mg/kg/day for 7 days) failed to affect the formation of the fibrocartilagenous and bony callus, but strongly inhibited the mineralization and calcification of the callus at two weeks after fracture.
At 4-6 weeks after fracture, resorption of the dead bone and remodelling of the callus were also inhibited and fracture callus seemed to be osteoporotic roentogenographically in EHDP-treated rats.
