we have already reported that EHDP inhibited the calcification of growth cartilage, which got thicker.
Now we give rats EHDP enough to stop the calcification of the growth plate, and follow the course of recovery with microangiography.
60mg/kg of EHDP were given subcutaneously everyday for a week. Soon after the last administration of EHDP, the growth plate got thicker and the vascularity of metaphyseal vessels decreased. 2 weeks after the dose, capillary buds grew into the plate aborescently and got calcified. After 4 weeks the capillary developed into more functional metaphyseal vessels, and there was already new primary cancellous bone.
