The influence of Cyclophosphamide (CY) on bone and cartilage tissue has been studied recently. We studied the effects of CY on rats and reported about the Osteopetro-Rickets' changes in tibia metaphysis. In this study, we examined the effects of CY on experimental tibia fractures. It was observed that CY 5mg/kg/day induced a delay in fracture healings and CY 10, 20mg/kg/day disturbed the fracture healings and induced pseudoarthrosis in them.
