CPPD結晶形成の pathomechanism
1985 年 34 巻 2 号 p. 608-612
詳細
1985 年 34 巻 2 号 p. 608-612
Articular and ligamentous tissues in 20 patients with calcium pyrophosphate dihydrate (CPPD) crystal deposition disease were studied by using histological, electron probe analysis and X-ray diffraction techniques.
Peculiar chondrocytes or metaplastic chondrocytes that seem to accumulate proteoglycans and inorganic pyrophosphate were seen constantly in the area of incipient formation of CPPD crystals. These cells appear to contribute formation of CPPD crystals by releasing inorganic pyrophosphate mostly from the portion showing destruction of cell membrane. The histological and histochemical findings in this study also indicate that proteoglycans play an important role in crystal growth by carrying high concentration of inorganic pyrophosphate on the crystal surfaces.
