抄録
When disks of PMMA were exposed to the cells of Staphylococcus E46, a thick adherent biofilm, composed of these bacteria and of their exopolysaccharide products (glycocalyx), developed on the PMMA surface within 24h. After this colonization, established biofilm on PMMA was exposed to PBS containing 2mg of cefotiam per ml, and a significant proportion of the bacterial cells within the biofilm were found to be still viable after 12h or 24h of exposure to this very high concentration of antibiotic. Floating cells taken from the test system were completely killed. These data indicate that growth within thick adherent biofilms confers a measure of cefotiam resistance on cells of Staphylococcus E46.
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