整形外科と災害外科
Online ISSN : 1349-4333
Print ISSN : 0037-1033
ISSN-L : 0037-1033
白鼠骨発育に関する内分泌学的研究
第1報 下垂体剔出の影響に関する実験的研究
赤津 隆
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1954 年 4 巻 1 号 p. 46-50

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I will report on influences on the bone growingg when hypophysectomy after Oyama's method, sacrified 96 rats.
I have been experienced for 14 weeks after hypophysectomy.
The hypophysectomy causes an immediate cessation on the bony growth, body weight and body length.
Summary of the experimental results;
1) After hypophysectomy the rat was suppressed bony growth hardly, but had not entirely suspended the development of the length diameter of long bones.
2) Histological changes of bone growth; 5 days, after hypophysectomy, I have observed the epiphyseal cartilages becoming narrow, and degenerated. After 2 weeks, the columnar arrangement of cartilage cells become irregular, after 3 weeks the bony cortex has been thinned, after 6 weeks the changes in all zone of epiphyseal cartilages, after 14 weeks, the trabeculae was almost disappearance, calcification was suspended.
The epiphyseal cartilages persisted long after the normal period for its ossification, but cartilage cells entirely degenerated.
3) The diameter of epiphyseal uncalcified portion was constant (after Li Evans method).
4) In the hypopbysectomized rats, I hove observed great changes in thyroid, gonads and adrenal cortex, small changes in thymus and Paro tis, and no changes in Parathyroid.
The brain weight was equal.

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