抄録
In order to monitor changes in the major matrix components following Chondroitinase ABC injection, immunohistochemistry was performed to demonstrate the localization of chondroitin sulfate, type I and type II collagen. Immunopositive staining for chondroitin sulfate was decreased in the inner annulus fibrosus at 2 weeks but recovered at 6 months. However, the amount of positive cells for chondroitin sulfate in the nucleus pulposus was not restored to the control level. In addition, morphology of the regenerated cells in the nucleus pulposus was not analogous to that of the control discs.
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