Changes of Bone Metabolic Markers and Bone Mineral Density in Osteoporosis Patients with Etidronate Therapy

Yuichi Arizumi; Naoya Tajima; Etsuo Chosa; Hiroshi Kuroki; Keisuke Goto; Norichika Kurihara

doi:10.5035/nishiseisai.50.1104

エチドロン酸ニナトリウム投与における骨代謝マーカーと骨塩量の変化について

有住裕一, 田島直也, 帖佐悦男, 黒木浩史, 後藤啓輔, 栗原典近

著者情報

キーワード: ビスフォスフォネート, エチドロン酸ニナトリウム, エチドロネート, 骨代謝マーカー, 骨密度

ジャーナルフリー

2001 年 50 巻 4 号 p. 1104-1106

DOI https://doi.org/10.5035/nishiseisai.50.1104

詳細

抄録

Between May 1998 and July 2000, we treated some osteoporosis patients with etidronate. Among these patients, we studied the changes of bone metabolic markers and bone mineral density in 17 cases. All cases were examined with bone metabolic markers such as osteocalcin (OC), pyridinoline (Pyr), and deoxypyridinoline (D-pyr). We also examined bone mineral density (BMD) using DXA in all cases.
Bone resorption makers (Pyr, D-pyr) decreased 3 months after beginning treatment, and bone formation maker (OC) decreased 9 months after beginning treatment. BMD in lumbar spine and femoral neck showed no remarkable changes. BMD in calcaneus increased 6 months after beginning treatment.
In this study, suppression of bone resorption was evident, but our research indicates that BMD increase occurs over a longer period of time.

責任著者(Corresponding author)

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