Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Case report
Esophagogastric variceal bleeding in a case of liver cirrhosis associated with thalassemia
Akihisa ISHIKAWAAtsushi OHKAWARANobushige KAKINOKIYosuke KISHIMOTOToshiro KAMOSHIDAShinji HIRAIYuji OKA
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2009 Volume 106 Issue 6 Pages 800-804

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Abstract

A 58-year-old man was admitted to our hospital because of hematemesis. Laboratory tests indicated microcytic hypochromic anemia and iron overload. We performed urgent endoscopic examination, and diagnosed bleeding from esophagogastric varices. Abdominal CT showed liver cirrhosis and marked splenomegaly, but no evidence of gastrorenal shunt. The varices were treated by Hassab's operation and splenectomy. Pathologic examination revealed hepatocytes in the cirrhotic nodules filled with iron pigment. The cause of the liver cirrhosis was considered to be due to iron overload resulting from thalassemia. We diagnosed the cause of the microcytic anemia as thalassemia by gene analysis, which revealed heterozygosity of a deletion (δβ thalassemia Jpn-type II) and one point mutation (-31A→G).

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© 2009 by The Japanese Society of Gastroenterology
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