胃冷凍法に関する実験的研究

抄録

Gastric freezing for 45 minutes was performed on 71 dogs according to the technique described by Wangensteen. In a laparotomized state, the gastric serosa temperature was recorded every 5 minutes on each dog during the freezing procedure. The main purpose was to do the fundamental analysis between the temperature compared with mucosal damage and the acid secretory function.
The results are as follows:(1) Marked edema inclusive of bleeding and erosion and /or ulcer in early stages had decreased remarkably within one week.(2) Light microscopically, early changes such as mucosal necrosis and edema were gradually reepithelized to have shown circumscribed atrophy of mucosa. Outside these areas the mucosa was normal.(3) On electron microscopy, the parietal cells showed almost no changes except completely frozen area, similar to the other report.(4) Even in the early period, strong acid secretion was observed with pH-test paper, if only the fundic glands were preserved.(5) Gastric blood flow reduced 60% immediately after freezing, but after 24-48 hours increased 55% more than the normal flow. These changes returned to the normal range after one week.
These results demonstrate the impossibility of acid decrease without destroying the fundic glands. For this purpose, the temperature of the gastric wall must be uniformly below the freezing point, but it seems uttermost difficult to equalize the gastric wall temperature under the present gastric freezing, unless we exclude the heat supplying sources such as the abdominal aorta, the liver and the spleen.