慢性肝炎の副腎皮質ホルモン療法についての一考察
1967 年 64 巻 8 号 p. 669-681
詳細
1967 年 64 巻 8 号 p. 669-681
Among 101 cases of chronic hepatitis, 41 were treated with corticosteroid and the rest served as control.
All the patients were hospitalized between May 1961 and April 1965.
The patients treated with corticosteroid received betamethazone from 2.0 to 4.0 mg as initial daily dosis and this was later reduced to maintenance dosis which was 1.0 to 1.5 mg daily. The average total dosis was 132.0 mg and duration of medication was 94.4 days.
Hepatic function tests, such as SGOT, TGPT, TTT, ZST, and AP, were examined once in a week and protein fractionation was carried out once or twice in every month.
From serial transaminase activity, these patients were divided into 5 patterns and effect or in fluence of corticosteroid on the hepatic function tests.
1) TTT, and ZST, were lower with corticosteroid administration, but after ceasing of it they started to rise again.
2) In protein fractions, the G-globulin was remarkedly reduced when dysproteinemia existed.
3) Generally SGPT level was higher than SGOT level in young adults and the reverse was observed in senile patients.
4) Rebound phenomena were frequently experinced in post transfusion viral hepatitis.
