食道炎の成因に関する研究 第2報

Shay ラツトにおける食道炎の発生と胃液量, 酸度との関係

抄録

Pylorus was ligated according to Shay's method in 45 rats. Thereafter the volume and acidity of gastric juice were measured and serial changes of esophageal mucosa were examined macro- as well as microscopically.
1) The significant increase in the volume of gastric juice was found postoperatively, and it amounted to 14.4±3.7ml 18 hours after the operation.
2) The pH of gastric juice was 2.4±0.28 before the operation, however, it rose temporarily to 4.6 after 2 hours followed by a decline to below 2.0 after 18 hours.
3) A significant invers correlation was observed between pH and logalithmic value of the volume of gastric juice.
4) Inflammatory changes were found macroscopically from 8 hours and microscopically from 4 hours after the operation, respectively. The incidence of esophagitis was increased as the intervals after the operation became longer. Esophagitis was found in all animals microscopically after 18 hours. The changes in esophageal mucosa closely resembled to those found in the idiopathic esophagitis of men.
5) The esophagitis was found frequently when the volume of gastric juice was increased or the pH was lowered to a great extent.
The foregoing findings indicated that esophagitis was clearly produced by the ligation of pylorus in rats and its morphological features closely resembled to human idiopathic esophagitis. It was suggested from the auther's observations that the secretory increase of gastric acidity might play an important role in the pathogenesis of esophagitis.