131I標識大凝集ヒト血清アルブミン (131IMAA) による門脈循環の研究
1968 年 65 巻 1 号 p. 58-68
詳細
1968 年 65 巻 1 号 p. 58-68
The possible existence of segregated streams of blood in the portal vein (stream line "phenomena in the portal vein) and their subsequent distribution to definite parts of the liver is of interest and was studied by many investigators. Although the portal stream-lining was proven in the dog, it could not be confirmed in man. In the present paper, some detailed investigations were made on "stream line" phenomena in the portal vein by the scanning method using 131I labelled macro-aggregated albumin (MAA) injection.
Two hundred 300μ Ci of 131I MAA, ranging 20-100μ in size, dissolved in 0.4-1.5ml saline solution, was employed as the indicator. 131I MAA injection was carried out in two different ways; into several radicles of the portal vein and the spleen. In the former, 11 cases of human subjects, having normal hepato-portal circulation, and 8 dogs were studied after laparotomy. Two minutes were taken for infusion in order not to disturb the stream line. Splenic injection was carried out in 30 cases of human subjects, including 19 cirrhotic cases (percutaneously) and 4 dogs (after laparotomy). The ultimate localization of 131I MAA in the regional capillaries of the liver was observed using scanning method for man externally and for the dog after removal of the liver.
The results obtained were as follows:
(1) When the injection of 131I MAA was made into tributaries of portal vein, the segmental istribution of radioactivity in the liver was observed in the most cases studied. Therefore the existence of "stream line" phenomena in the portal vein can be confirmed not only in the dog but also in man.
(2) When injection was made into the spleen, the diffuse distribution of radioactivity in the liver was found for the dog and non-cirrhotic human subjects. This fact will indicate the presence of complete mixing of blood flowing out from the spleen, in spite of the existence of "stream line" phenomena in the portal vein.
(3) By similar intrasplenic injection cirrhotic cases show predominant distribution of radioactivity in the left lobe, indicating the increased inflow of portal blood into this side of the liver.
