1968 Volume 65 Issue 11 Pages 1163-1178
Reports on the clinical use of radiocapsule for gastrointestinal pH measurement are few in number in spite of its comparatively long history of development. Secretory function of the stomach is revealed dynamically by alkalitest (Nöller) but the iterpretation of its results has not been discussed sufficiently. In this study the alkalitest was carried out under several conditions and some considerations were given on the problem of its interpretation. pH value was measured in the small bowel too. It was revealed that the pH fluctuated with stomach evacuation and it proved rather acid along the course of the jejunum.
Therefore present regulation on the condition of the"entericcoating"of tablets which should be dissolved in the small bowel must be reexamined. And a consept of the"stabilising level"of pH curve after administration of an antacid was presented which may be useful for the evaluation of the drug.