膵外分泌機能に関する実験的研究

抄録

It has been said that the function of the external secretion of the pancreas is related both to nervous control and humoral control. Study along these lines has been remarkably developed in the field of physiology and patho-physiology in recent years.
In our series of experiments on the external secretion of the pancreas, gastrointestinal hormones (secretin, pancreozymin, ) nervous stimulants (epinephrine, pilocarpine, atropine), and pancreatic secretion inhibitors (acetazolamide, anti-kallikrein substance, trasylol), were used and the relationship between pancreatic secretion and pancreatic blood flow were studied.
Plethysmogramm was used to measure the blood flow. Furthermore, observations of the influence of the above-mentioned drugs by electron-microscopy and histo-pathological methods, were carried on pancreas tissue. The following results were obtained:
1) Secretin increased the quantity of pancreatic blood flow and pancretic secretion at the same time, however, from the morphologic point of view, no progress was observed in the process of enzyme secretion in a pancreatic cell.
2) Pancreozymin increased the quantity of pancreatic blood flow and pancreatic secretion, however, it caused a lower ratio of increase compared with secretin. Also, from the morphologic point of view, enzyme secretion was observed to be remarkably similar to the electronmicroscopic findings of pilocarpine. Further, there may be some relationship between pancreozymin and nervous control.
3) In the use of epinephrine, decrease of pancreatic blood flow and decrease of pancreatic secretion were observed, however, in case of pilocarpine, the pancreatic blood flow decreased while pancreatic secretion increased indicating that the amount of pancreatic blood flow was not parallel to pancreatic secretion.
4) Histological findings indicated that pancreozymin has the function of stimulating pancreatic enzyme secretion.
5) The process of pancreatic external secretion, has both secretin function and pancreozymin function, and the functioning point of secretin is located in the centro-acinal cell and pancreatic ductal cell, while that of pancreozymin is located in the acinal basal cell.