2•3の条件下におけるBSP排泄機構
サリチル酸ソーダ応用時の研究
1968 年 65 巻 9 号 p. 928-933
詳細
1968 年 65 巻 9 号 p. 928-933
Rat's experiments were undertaken to examine the alterations of steps involved in the transfer of BSP from blood to bile following an intravenous administration of sodium salicylate.
1) Following a single intravenous administration of BSP, a moderate degree of choleresis and a significant increase of biliary excretion of BSP were observed.
2) Distribution of BSP was examined after a constant infusion of BSP. The maximal transport of BSP into bile (biliary BSP-Tm) was unchanged through a constant intravenous administration of sodium salicylate. A significant increase of hepatic BSP storage, in unconjugated form, was demonstrated.
3) Through an addition of sodium salicylate a significant inhibition of BSP-binding affinity of plasma albumin and a distinct release of BSP from BSP-bound serum were demonstrated in vitro. No acceleration of BSP-glutathione conjugating enzyme activity was demonstrated.
4) It was concluded that an increase of biliary excretion of BSP by sodium salicylate was brought about through an inhibition of BSP-plasma albumin binding.
