消化器疾患における嫌気性菌の研究

第1編 嫌気性菌を主とした胆石症•胆嚢炎の起炎菌の研究

抄録

The bile of resected gall bladders was drawn off and cultured both aerobically and anaerobically (by Steel-Wool Method) in 100 cases of cholecystitis and/or cholelithiasis.
1) The bacilli are isolated in 46 cases (46%) out of 100 cases: 13 cases (13%) of anaerobic, 29 cases (29%) of aerobic and 4 cases (4%) of combined infection.
2) The average count of bacilli in 0.5ml of bile are 10^4.3 in anaerobes and 10^6.6 in aerobes.
3) The strains of isolated anaerobes were 6 strains of Corynebacterium, 5 of Eubacterium, 2 of Clostridium welchii, 1 of Bacteroides, 2 of Peptostreptococci and 1 of Veillonella. The ratio between rods and cocci was 82.3% to 17.7%.
4) High fever is seen in aerobic (34.5%) anaerobic (30.8%) and combined infections(25.0%).
5) Upon histological examinations of removed gallbladder, it is concluded that non-spore forming anaerobes may participate in causing acute and chronic cholecystitis.
6) The non-spore forming anaerobes are proved to be highly sensitive to TC, DMC-TC, DOTC, AB-PC, MCI-PC, CER, CET, Fs, AT and moderately sensitive to PC, CP, EM, OM, LM, LCM and GM. Low sensitivity is encountered in KM, SM, NA, SX and CL.
7) Anaerobes are highly sensitive to various bile acid such as cholic acid, desoxycholic acid, Sodium taurocholate and sodium glycocholate, compared with aerobes.
The difference of the sensitivity to the bile acids between aerobes and anaerobes may reflect upon the difference of the detection rate (7:3) between both organism groups in bileduct infections.