Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
A Phase Contrast Microscopic Study of Exfoliated Cells of The Stomach
T. Katayanagi
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1969 Volume 66 Issue 11 Pages 1293-1310

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Abstract

I Morphological characteristics of exfoliated gastric cells.
Exfoliated gastric cells in advanced carcinoma, early carcinoma, ulcer, polyp, and normal lining epithelium were studied by means of phase contrast microscopy and morphological characteristics of each disease entity were disclosed.
(1) Irregular nucleoli appeared most frequently in cancer particulary in early carcinoma of the type IIa.
(2) Mitochondria was small in size and number in carcinoma cells.
(3) In fresh specimen, the nuclear membrane of advanced cancer cells appeared thickened, whereas that of benign cells were usually not thickened, and the cells of early carcinoma were placed in the middle. In an early period of degeneration, the increase in nuclear wall material showed different appearances in malignant and benign cells; it appeared irregulary serrated in the former whereas smooth thickening was noted in the latter.
(4) The appearances of halo around the nucleoli and of chromatin about the nucleoli are also of diagnostic value. In most of malignant cells the halo is clear with little chromatin granules within the area, whereas in non-malignant cells chromatin agrregates towards the nucleoli with some decrease in volume in the area of halo.

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© The Japanese Society of Gastroenterology
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