実験的肝 outflow block におけるリンパの変化

抄録

Evidences have been accumulated to show the important role of hepatic lymph in the hepatic circulation. This is especially true when disturbance of hepatic outflow exists.
In four groups of dogs, I studied the following items: Hemodynamics of heart, circulation in the liver, sodium space in liver tissue, thoracic lymph flow rate, time of appearance of Na²⁴ into thoracic duct after intravenous injection, turnover rate RISA, protein content, transaminase and lactic dehydrogenase activity in serum and lymph.
Group I: Acute constriction of supradiaphragmatic inferior vena cava
Group II: Ascitic dogs, induced by chronic constriction of supradiaphragmatic inferior vena cava
Group III: Cardiac cirrhosis dogs, induced by tricuspid valvotomy and pulmonary artery stenosis
Group IV: Hepatic fibrosis dogs, induced by carbon tetrachloride
The results of this experiment will be summarized as follows:
1. Hepatic blood flow decreased most markedly because of the decreased cardiac output and the ratio of hepatic blood flow to cardiac output was slightly low than normal in dogs of Group III.
2. Protein-losing enteropathy developed in Group III and was not observed in dogs of Group II & IV.
3. In Group II cardiac cirrhosis dit not result.
4. In normal dogs, the time of appearance of Na²⁴ into thoracic duct is within 3 minutes after intravenous injection.
5. When hepatic venous blood outflow exists, this time of appearance was shortend and sodium space in the liver tissue increased in parallel with the elevation of hepatic venous pressure.
6. Albumin concentration in lymph was higher than in serum in all groups of dogs. Increase of thoracic lymph flow rate and albumin concentration was due to the increased permeability of sinusoid in dogs with disturbance of hepatic venous outflow.
7. Transaminase activity in serum was in general higher than in lymph. Increased transaminase activity after acute constriction of inferior vena cava was, however, higher in lymph than in serum. Lactic dehydrogenase activity was higher in serum than in lymph in all groups of dogs.