2•3の条件下におけるBSP排泄機構

デヒドロコール酸ソーダ応用時の実験的研究

抄録

Rat experiments were undertaken to examine the alterations of steps involved in the transfer of BSP from blood to bile after the intravenous administration of sodium dehydrocholate (DHC).
1) Following a single intravenous administration of BSP, biliary excretion of BSP was increased by DHC.
2) Distribution of BSP after a constant infusion of BSP wasestimated. Through the intravenous administration of DHC, a distinct increase of bile output, a moderate degree of elevation of the maximal transport of BSP into bile (BSP-Tm) and a distinct decrease of hepatic storage of BSP (BSP-S) were observed.
3) Through an addition of DHC an inhibition of BSP-binding affinity of plasma albumin and a distinct acceleration of BSP-glutathione conjugating enzyme activity were observed in vitro.
4) It was concluded that an increased biliary excretion of BSP by DHC was resulted from an elevated BSP-Tm, increased bile output, inhibited BSP-binding of plasma albumin, increased BSP-glutathione conjugating enzyme activity and decreased hepatic BSP storage.